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Managing Parkinson’s in the ED

Author: Sally Jones / Codes: CAP12, CAP2, CAP30, CAP4, CAP8, CC1, CC2, CC3, CC4, CC5, CC6, HAP1, HAP13, HAP35, HAP36, HMP5 / Published: 26/09/2016

The case

Your patient is a 70 year old lady with a history of type 2 diabetes and Parkinsons disease, for which she is on a number of medications. She is usually fairly independent but fell in the kitchen whilst preparing her lunch, hurting her hip and banging her head on the hard tiled floor.

She couldnt get up and so remained on the floor, fully conscious but in considerable pain until her daughter called round on her way home from work at approximately 6pm. She has been in the department for 4 hours now and has sustained a fractured pubic ramus. She also had a CT head scan but this was essentially normal.

The SHO is worried because when she first took the history the patient was alert and chatty but she started hallucinating after being given opiate analgesia and was quite agitated with this.

Since the team were worried this may have been secondary to her head injury rather than the opiate, she was given a small dose of intramuscular haloperidol in order to help her comply with a CT head scan and the agitation quickly settled.

However, on returning to review her later, the patient has dramatically deteriorated. She is now struggling to speak and is drooling. She couldnt swallow the tea the nurses tried to give her. She now cannot sit up unaided, her posture has changed and she is struggling to hold her head up from her chest. Her daughter is very distressed. Blood sugar and observations are normal. The patient has been referred to the medical team but it is likely to be some time before they can assess her.

Three things are probably going through your mind at the moment:

  1. What has happened?
  2. What must you do?
  3. What must you NOT do?

Parkinson’s in the ED

The crucial part of her history is her Parkinsons Disease (PD). Parkinsons medications are time critical and during her time on the floor at home as well as her time in the ED, she has almost certainly missed several doses of her Parkinsons medication (it’s hard to overestimate how often this happens and similarly in epilepsy).

She has also been given haloperidol which is contra-indicated in Parkinsons.

This patient urgently needs her PD medications. These will now have to be given via nasogastric (NG) tube since the patient is unable to swallow. This must be done as a priority. A transdermal patch (of rotigotine) is available if the NG is not possible, but the first line option is to give her usual medications urgently via NG.

It is also important to check the patients CK. Not only has this patient had a long lie, but people with Parkinsons can develop a Neuroleptic Malignant Syndrome like disorder if their medications are suddenly stopped or if they are given a dopamine antagonist such as haloperidol, as in this case.

Haloperidol
Haloperidol and other anti-psychotics, prochlorperazine and metaclopramide block Dopamine and are contraindicated in Parkinsons.

It is vital not to delay the giving of Parkinsons drugs. Even though it is a very busy department, you must not simply refer to the medical team to sort out her medication later, particularly as you know they are likely to take some time. Any additional delay to this patient receiving her medication risks rapid further deterioration and life threatening complications such as neuroleptic malignant syndrome, aspiration pneumonia and pressure ulcers.

So what is Parkinsons Disease (PD)?

Many people think Parkinsons (PD) is just a tremor, but it is much more than this. Parkinsons is a complex neurodegenerative condition. It is not completely understood but is related to the progressive loss of dopamine producing neurons within the brain. The triad of signs commonly quoted is tremor, rigidity and bradykinesia. However, Parkinsons has many additional signs and symptoms, both motor and non-motor, which affect patients lives in many different ways.

Motor Symptoms

  • Tremor
  • Rigidity
  • Bradykinesia (slowness of movement) with difficulty initiating movement
  • Dyskinesia (abnormal movement, eg wriggling)
  • Postural instability (increases risk of falls)
  • End of dose deterioration (deteriorating before next tablet is due)
  • Freezing (periods of being unable to move)
  • Motor fluctuations (alternating between dyskinesia and bradykinesia).

Non-motor Symptoms

  • Autonomic postural hypotension, urinary urgency, erectile dysfuntion
  • GI nausea, constipation (can be severe), volvulus
  • Neuropsychiatric depression, anxiety, hallucinations, REM sleep disorder, cognitive impairment (including PD dementia), impulse control disorders, at risk of delirium
  • Speech and Swallow drooling, dysarthrophonia, impaired swallow
  • Respiratory aspiration pneumonia if impaired swallow

Why do I need to know about PD in ED?

People with PD rarely present purely because of PD itself. However, patients may attend ED with complications of their PD (for example falls, delirium, severe constipation or aspiration). In addition, PD may complicate the presentation and treatment of any emergency for example pre-existing autonomic instability will make sepsis or hypovolaemia more difficult to assess, and the requirement to take regular time critical medications makes managing reduced conscious level or need for sedation/anaesthesia more difficult. Patients in ED may delay/miss their PD medication since this may not be seen as the immediate priority by ED staff. This can cause life threatening complications.

Emergency presentations in PD

Cardiovascular

Postural hypotension is common in PD. This may be the presenting complaint or can complicate any condition causing haemodynamic compromise.

Respiratory

Aspiration pneumonia due to impaired swallow -ensure medication is not missed.

Gastroenterology

Constipation can be severe. Sigmoid volvulus can occur and may be recurrent.

Falls

Often multi-factorial but remember PD itself causes postural instability and postural hypotension. Added to this there may be other contributing co-morbidites. Any acute illness can also lower the threshold to fall. Dont blame PD without excluding acute illness.

Medication related

Patients may develop nausea, delirium, hallucinations or postural hypotension after medication changes. Speak to local PD team for advice.

Missed PD medication or administration of dopamine antagonists (most anti-psychotics, including haloperidol; metoclopramide and prochlorperazine) can cause rapid deterioration. Neuroleptic Malignant Syndrome may result – give their PD medication urgently, via NG if necessary.

Psychiatry

Hallucinations, depression and anxiety are common. Patients may have PD related cognitive impairment or dementia and are vulnerable to delirium. Rarely patients may develop dopamine dysregulation symptoms and may shop around ED departments for extra medication.

Remember: People with PD can present with any emergency condition. The pitfall is focussing exclusively on the presenting complaint and overlooking the PD. This may impact on the emergency assessment and will deteriorate rapidly if time critical medications are delayed or missed.


References/further reading:

  1. HEFT: Parkinson’s Disease
  2. Parkinson’s UK: Emergency Management of Patients with Parkinson’s
  3. LITFL: Parkinson’s
  4. Wiki EM: Parkinson’s

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14 Comments

  1. sivas5935 says:

    crisp and concrete module Very good diagramatic illustration

  2. DJ Hamblin-Brown says:

    This is really helpful summary. I will be using this with my juniors. Concise and relevant. Thank you Sally.

  3. gajossa says:

    very helpful:)

  4. singhsh says:

    very very good , very useful !!!

  5. Maxwell Richardson says:

    Very good and very helpful summary

  6. Ryan Ghodrat says:

    Very interesting module. Many hospitals have policy of Medics completing drug chart which can easily add another 4-6 hours post ED review on a busy medical take.

  7. hurryr5717 says:

    Really useful! Many thanks!

  8. krishnappaa says:

    Very precise and hepful.

  9. Juan Pedro says:

    Thank you for the topic, great help to review PD and urgency of treatment

  10. kandaratnami5783 says:

    very relevant

  11. tminns says:

    useful, thank you, can all PD meds be safely crushed for NG administration?

  12. hathiarin6842 says:

    Very useful, thank you!

  13. Neil David Baars says:

    Lots of great pearls in this article. Thanks very much for taking the time.

  14. Peter Stewart Kelly says:

    A very useful and relevant summary.

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