Risk Stratification

Group A Streptococcal infection is more likely in the winter/spring, and in children aged 5-15.

To differentiate between viral causes, and the potentially more serious GABHS infection, a number of tools have been developed to assess the probability of GABHS infection and therefore the need for antibiotic treatment.

The two recommended by NICE [15] are FeverPAIN and CENTOR.

FeverPAIN Score 0-5 (Each scores 1 point)
Fever over 38°C.
Purulence (pharyngeal/tonsillar exudate)
Attend rapidly (3 days or less)
⦁ Severely Inflamed tonsils
No cough or coryza

CENTOR Score 0-4 (Each scores 1 point)
⦁ Tonsillar exudate
⦁ Tender anterior cervical lymphadenopathy or lymphadenitis
⦁ History of fever (over 38°C)
⦁ Absence of cough

A modified version of CENTOR adds in age to increase accuracy, but is not currently included in NICE guidance [10].

Scores and subsequent likelihood of isolating Streptococcus [15].

FeverPAIN CENTOR
0 – 1 13 – 18% 0 3%
2 – 3 34 – 40% 1 7%
4 – 5 62 – 65% 2 15%
3 32%
4 56%

Learning bite

A sore throat score is useful in predicting the likelihood of GABHS infection and can reduce unnecessary antibiotic prescriptions by 50%.

Note that these scores are not applicable to other causes of sore throat other than tonsillopharyngitis.

4 Comments
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Adrian Grzegorz Zebrowski October 23, 2018 at 5:44 am

Very useful grading- could rduce the antibiotic overprescribing

Adrian Grzegorz Zebrowski October 23, 2018 at 5:46 am

On a simple presentation as sore throat we may assess the patient and prevent more severe complications when the infection developes and becomes multisystemic

Md Mahbubur Rahman Siddique September 10, 2022 at 1:06 pm

It was precious information

Mrs Cheryl Ann Barnes October 19, 2022 at 12:31 pm

good information thank you

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