Context and Definition

Anaphylaxis is a severe, life-threatening, multi-organ hypersensitivity reaction, typically of rapid onset.

There are at least 20 deaths attributable to anaphylaxis in the UK each year [1].

The incidence of anaphylaxis is increasing [1].

The early recognition of anaphylaxis and its prompt treatment with adrenaline, is highly likely to prevent deterioration.

No randomised controlled trials regarding the critical management of anaphylaxis exist, or are likely to exist.