There is no role for anti-histamine use in the immediate treatment of anaphylaxis. After the patient has been stabilised, a non-sedating anti-histamine can be given to help alleviate cutaneous symptoms.
The routine use of corticosteroids to treat anaphylaxis is not advised. If the patient is suffering from ongoing asthma/shock after initial resuscitation steroids may be considered, however must not be given preferentially to adrenaline. There is little evidence that steroids shorten symptoms or prevent biphasic reactions.[1]