Use of Anti-D

Current guidelines state that Anti-D immunoglobulin should be administered as soon as possible and always within 72 hours of a sensitising event [26].

In pregnancies <12 weeks gestation, Anti-D is only indicated following ectopic or molar pregnancies, therapeutic termination of pregnancy and in cases of heavy or repeated uterine bleeding, or bleeding associated with abdominal pain. The minimum dose is 250IU, and a Kleihauer test is not required.

For potentially sensitising events between 12 and 20 weeks, again the minimum dose is 250IU, and a Kleihauer test is not required.

After 20 weeks, a minimum dose of 500IU of Anti-D immunoglobulin and a Kleihauer test are both required.