Context and Definition


Sudden cardiac death (SCD) accounts for 15–20 % of all deaths worldwide and is a cause for major concern1.

Causes of SCD differ among the various age groups. In the younger person, the most common causes are cardiomyopathies, channelopathies, illicit drug use, and myocarditis2.


Brugada syndrome is an autosomal dominant genetic disorder, with a male preponderance, characterized by abnormal findings on the electrocardiogram (ECG) along with an increased risk of ventricular tachyarrhythmias and sudden cardiac death3.

Typical ECG changes are that of ST-segment elevation in V1 and/or V2 with a coved ST-segment, sometimes described as a pseudo right bundle branch block4.

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