The exact pathophysiology is not clearly understood but various mechanisms have been found. Genetic analysis has led to the identification of certain causative mutations in the specific genes, which encode for subunits of a cardiac sodium channel.

The problematic sodium channels in the myocardium, reduce sodium inflow currents, and shorten the duration of the action potentials. This makes the heart more susceptible to arrhythmias5.

Learning bite

Brugada syndrome is a genetic sodium channelopathy resulting in cardiac dysrhythmias that can lead to sudden cardiac death.

Post a comment

Leave a Comment