Author: Rajesh Chatha / Editor: Rajesh Chatha, Robert Hirst / Codes: IP3, RP6, SLO10, SLO3 / Published: 24/02/2022

At TERN Education we are keen to help you learn how to critically evaluate the evidence base behind your practice. In order to do this, we have been producing monthly virtual journal club (VJC) modules on RCEMLearning since March 2021.

Welcome to February 2022’s Virtual Journal Club Module. This month’s edition is written by the TERN Education team and it looks at fluid resuscitation in sepsis.

Are you interested in writing a module? We are looking to recruit regional teams around the country to write future Modules from August. Email us on [email protected].

References

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  2. The PRISM Investigators. Early, Goal-Directed Therapy for Septic Shock – A Patient-Level Meta-Analysis. The New England Journal of Medicine. 2017; 376(23): 2223-2234. doi:10.1056/NEJMoa1701380
  3. Henning DJ, Shapiro NI. Goal-Directed Resuscitation in Septic Shock: A Critical Analysis. Clinics in Chest Medicine. 2016; 37(2): 231-9. doi:10.1016/j.ccm.2016.01.016
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  9. Kabil G, Frost S, Hatcher D, Shetty A, et al. Early fluid bolus in adults with sepsis in the emergency department: a systematic review, meta-analysis and narrative synthesis. BMC Emergency Medicine. 2022; 22(1): 3.
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  11. Andreas Perner. The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial (CLASSIC). [accessed 23 February 2022].
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  16. The PETAL Network. CLOVERS: Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis. 2022. [Accessed 22nd February 2022]
  17. Sepsis Research. EVIS [Accessed 22nd February 2022]
  18. Douglas I, Alapat P, Corl K, Exline M, et al. Fluid Response Evaluation in Sepsis Hypotension and Shock. A Randomized Clinical Trial. Chest. 2020; 158(4): 1431-1445. doi:10.1016/j.chest.2020.04.025
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