Guillain-Barre Syndrome

Pathophysiology and Variant Forms

Clinical Features

Complications and Risk Stratification

Differential Diagnosis

2 Topics

2 Topics

Initial Treatment

Treatment Options

2 Topics

Guillain-Barré syndrome – Post Test

Guillain-Barré syndrome – Post Test

Guillain-Barre Syndrome Guillain-Barré syndrome – Post Test

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Question 1 of 10

1. Question
Which of the following represents the fundamental pathophysiological changes found in GBS?
- Muscle wasting
- Demyelination of axonal nerve fibres
- Destruction of neuronal cell bodies
- Swelling of spinal cord nerve roots
- Plaque formation in cerebral cortex
Question 2 of 10

2. Question
Which of the following, from history and examination, are indicative of the diagnosis of GBS?
- History of recent foreign travel
- Predominantly sensory symptoms
- Previously well for last three months
- Symmetrical motor weakness
- Well-defined sensory level
Question 3 of 10

3. Question
Which of the following investigations is indicative of the diagnosis of GBS?
- Fever at presentation
- Raised lymphocyte count in CSF
- Raised polymorph count in CSF
- Raised protein in CSF
- CT brain abnormalities
Question 4 of 10

4. Question
Which of the following investigations is not indicated acutely in a typical case of GBS?
- CT head
- Lumbar puncture
- Stool culture
- ECG
- Urea and electrolytes
Question 5 of 10

5. Question
Which of the following monitoring is indicated acutely in a typical case of GBS?
- Continuous ECG monitoring, with regular blood pressure checks
- Hourly Glasgow coma scale scores
- Hourly lung function tests
- Hourly capillary blood glucose
- Urine output
Question 6 of 10

6. Question
In a patient with GBS who is severely affected (unable to walk), which of the following treatments are indicated at presentation?
- Oral corticosteroids
- Systemic broad spectrum antibiotics
- Intravenous immunoglobulin followed by plasma exchange
- Plasma exchange followed by intravenous immunoglobulin
- Intravenous immunoglobulin or plasma exchange
Question 7 of 10

7. Question
Which of the following is not an indication for admission to the ICU?
- Miller Fisher syndrome
- Swallow reflex affected with high risk of aspiration
- Highly labile blood pressures
- FVC less than 20mL/kg
- Rapidly-progressive weakness with respiratory compromise
Question 8 of 10

8. Question
Regarding Miller Fisher syndrome, which of the following is correct?
- Sensory loss is common
- It is most common in western Europe
- Ophthalmoplegia is almost invariably seen
- Ataxia is rarely seen
- Limb weakness is often severe
Question 9 of 10

9. Question
Which of the following is indicative of a good prognosis in GBS?
- C jejuni found on stool culture
- Miller Fisher syndrome
- Severe disability at presentation
- Increasing age
- Male sex
Question 10 of 10

10. Question
Which of the following are indicative of a diagnosis other than GBS?
- Raised CSF protein count
- Absence of white cells in CSF
- Cranial nerve involvement
- Fever at presentation
- Primarily motor symptoms

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