Signs and Symptoms of Hypercalcaemia

The severity of symptoms is not always related to the degree of hypercalcaemia, but often reflects the rapidity of onset. Patients do not always exhibit all of the clinical features. The onset of hypercalcaemia may be insidious.


Fatigue, lethargy, confusion, myopathy, hyporeflexia, seizures, psychosis and coma. The most frequent effect of hypercalcaemia is delirium.

Dehydration, polydipsia, polyuria, pruritis. Weakness and bone pain may also be present.


Anorexia, nausea and vomiting, weight loss, constipation, ileus and abdominal pain.


Shortened QT, prolonged PR, Wide and flattened T waves, J waves, Ventricular and Atrial Arrhythmias and Bradycardia which can be fatal

Polyuria, polydipsia, dehydration and development of kidney stones.

Polyuria, nocturia, polydipsia, dehydration, anorexia, easy fatigability, weakness, hyporeflexia, pain may be precipitated or exacerbated by hypercalcaemia.


Apathy, irritability, depression, decreased ability to concentrate, obtundation, coma, profound muscle weakness, nausea and vomiting, constipation, increased gastric acid secretion, acute pancreatitis, pruritus, visual disturbances, sudden death from cardiac dysrhythmias may occur if calcium rises quickly, especially in patients taking digoxin.

Learning bite

In unexplained vomiting, thirst, polyuria or confusion, it is prudent to check serum calcium.