For a severely poisoned patient, PPE may be required.

The patients should be resuscitated and atropine given to a point where the pupils are just starting to dilate and bronchospasm stops. This may require repeating as the half-life of many organophosphates is longer than the Atropine.

Pralidoxime has a longer time of effect and may be used for poisoning with organophosphorus compounds with anticholinesterase activity.

Other toxins and their antidotes include the following:

Toxin Toxidrome Antidote
Organophosphates Pinpoint pupils, drooling saliva, urination, diarrhoea, and emesis Atropine and Pralidoxime
Carboxyhaemoglobin Normal pupil size, pink or cyanosed skin, decreased conscious level and decreased respiratory rate Oxygen
Hydrogen Sulphide Mydriasis, cyanosis and increased respiratory rate Sodium Nitrite
Methaemoglobin Normal pupil size, cyanosis despite good oxygenation and decreased respiratory rate Methylene Blue
Hydrofluoric acid Rapid onset severe pain and erythema Calcium Gluconate