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A 50-year-old man presents to the emergency department with lethargy and itching. His wife has noticed he has become yellow over the last three days.
He is on Mesalazine for ulcerative colitis and drinks approx 15 units of alcohol per week. His initial blood tests reveal bilirubin 70, ALT 220, ALP 1530. His pANCA is positive and Abdominal USS shows no dilatation of intra or extrahepatic bile ducts.
Which one of the following is correct.
Which of the following statements is correct regarding causes of jaundice:
Breakdown of haem is responsible for the majority of bililrubin produced but 20% comes from other sources.
Which of the following sources do NOT produce bilirubin?
Which one of the following statements is correct regarding metabolism of haem?
Which of the following does NOT cause obstructive jaundice?
A previously fit and well 75-year-old female is admitted for elective total hip replacement.
Intra-operatively she requires red cell transfusion of 4 units, fully cross matched. One week post operation, one of the nurses notes her to be jaundice. An FBC reveals Hb 8.5 g/dl, WCC 10.5 x10, plt 445 x10.
The most likely cause of her jaundice is:
In pre-hepatic (unconjugated) hyperbilirubinaemia the urinalysis will show:
With regards to management of patients presenting to the emergency department with jaundice, which of the following statements is correct?
A 60-year-old male with a longstanding history of alcohol excess, presents with weight loss, jaundice and abdominal pain. His total and conjugated bilirubin levels are raised. His ALT, GGT and amylase are raised. CT abdomen reveals nodular liver and cysts within his pancreas and a mass at the head of the pancreas. The most likely cause of jaundice is:
Which one of the following is true in jaundice caused by cholangiocarcinoma?
Good explanation
Best revision for the physiology and clinical concepts for the liver diseases