Hepatocellular Injury

Patients with hepatocellular injury, coagulopathy, and altered mental status may have acute liver failure also known as ‘Fulminant Hepatic Failure’ (FHF).

Patients presenting with FHF require fluid resuscitation, haemodynamic monitoring, and admission to a critical care area for supportive care.

The most common causes of FHF are Paracetamol poisoning (in the UK) and acute Hepatitis B (worldwide).

Prior to liver transplantation, the mortality of FHF was greater than 80%.