There are a number of pitfalls to be aware of in the assessment and management of jaundice:

  • Assuming, if USS is negative, that there is no intraparenchymal disease of liver or pancreas
  • False negatives for bilirubin in the urine occur with rifampicin
  • False positives for urinary urobilinogen occur in acute porphyria
  • High levels of Vitamin A or carotene can cause a patient with normal bilirubin levels to appear jaundiced
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