A-a Oxygen Gradient
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1. Question
The alveolar gas equation allows calculation of the alveolar O2 tension (PAO2).
PAO2 = (PB - PH2O) x FiO2 – (PaCO2/0.8)
PAO2 = 95 x FiO2 – (PaCO2/0.8)
Under normal circumstances the difference between this and the arterial O2 tension (PaO2) measured by the ABG machine is 2-4 kPa. This difference is known as the A-a gradient. Its calculation can help to distinguish between types of hypoxia.
In which of the following cases is the A-a gradient normal and in which is it increased?
Drag the types of hypoxia to the appropriate box.
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- Neuromuscular disease, Pure hypoventilation, Drug overdose
- Diffusion abnormalities, Right-to-left shunt, V/Q mismatch
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Normal A-a Gradient
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Increased A-a Gradient
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