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A 64-year-old female presents to the emergency department with confusion, fever and rigors over the preceding 24 hours. She is on continuous intravenous prostacyclin for the treatment of secondary pulmonary hypertension (due to sarcoidosis) via a tunnelled central venous Hickman catheter.
On examination, she is pale and clammy; her temperature is 38.7oC pulse is 110 per minute; BP is 90/65; SaO2 is 96% on air; respiratory rate is 28 per minute. She has normal heart sounds and lung auscultation revealed normal breath sounds. The catheter exit site is not inflamed.
Which of these are the three most urgent interventions for this patient?