Stroke Mimics

This table describes the clinical differences between strokes and stroke mimics.

Mimic

Clinical differences between a stroke and the mimic

Migraine

Often associated with an aura: a ‘positive’ symptom. A stroke involves loss of neurological function i.e. ‘negative symptoms’

Note: Headache is not a feature of ischaemic stroke but is often associated with intracerebral haemorrhage.

Hypoglycaemia A bedside glucose test will identify this clinical situation. All thrombolysis protocols require exclusion of hypoglycaemia
Seizure Seizures may be a complication of an acute stroke or may develop in someone with a history of stroke. However, presentation with a seizure is shown to reduce the odds ratio of the patient having a stroke (OR 0.28)
Brain tumour, space-occupying lesion or sub dural Usually more gradual onset, though features may be the same. This will be rapidly distinguished on brain imaging
Sepsis The patient usually has systemic symptoms of sepsis such as fever. Severe sepsis associated with systemic hypoperfusion may cause watershed area neurological dysfunction
Syncope Stroke rarely presents with syncope alone
Toxic metabolic states Hyperglycaemia and hyponatraemia can present with focal neurology. Confusion and slurred speech may be present
CN VII nerve palsy A peripheral VIIth cranial nerve palsy is a lower motor neuron lesion, and so the whole of one side of the face is weak. In an upper motor neuron lesion from a stroke (MCA territory), only the lower two-thirds of the face is weak