Factors influencing tissue healing

Local Factors:

• Devitalized tissue
• Clot
• Foreign Bodies
• Infection
• Tissue hypoxia
• Acute Vascular damage or tight sutures
• Chronic
  • Diabetic microvascular disease
  • Atherosclerosis
  • Venous Hypertension

Systemic factors:

• Nutritional deficiency Vitamin A, C, protein and zinc
• Drug treatment: glucocorticoids and cytotoxic drugs
• Diabetes
• Body irradiation
• Hypercatabolic states
  • Neoplasia, Jaundice, Uremia, Burns