Author: Henry R Guly / Editor: Jason M Kendall / Reviewer: Grace McKay / Codes: CAP3, HAP2, MuC1, MuC5, MuP1, NeuP8, SLO4, TP8 / Published: 25/03/2021
Back pain is common. It is estimated that 60-80% of the population have back pain at some time during their life with between 14-30% having some pain on the day of interview and 30-40% of people reporting some pain within the previous month.
Approximately 5-10% will have some degree of back trouble for long periods of their life, while 3-4% of the population aged 16-44 and 5-7% of those between 45 and 64 will report back problems as a chronic sickness .
Consequently, not only do emergency departments (EDs) see many patients presenting with acute back pain but they also see many with acute exacerbations of a chronic back problem and patients with back pain incidental to their presenting problem.
Emergency physicians must be able to differentiate serious from less serious causes of lower back pain. Most patients with serious causes will be referred to specialities for assessment and review, however the ED will manage less serious causes of back pain.
Back pain tends to start between the late teens and the late forties or early fifties. It is more common in smokers and there seems to be an association between back pain and the inter-related factors of low social class, manual work and low educational achievement. There is a definite association between manual work and time off work because of back pain .
The lifetime incidence of true sciatica is much less (about 5.3% in men and 3.7% in women) .
As with any patient in pain, one should take a full history of the pain. The PQRST mnemonic may be useful:
- Provocative and Palliative factors
- Quality of pain
- Severity and Systemic Symptoms
In particular, it is important to enquire for symptoms suggesting serious underlying pathology. These are known as Red Flags and are shown in Table 1:
Table 1: Red flag symptoms indication possible serious spinal pathology , 
|Onset at age <20 or >55|
|Non-mechanical pain (i.e. unrelated to time or activity), especially if constant and worsening and pain at night|
|Previous history of carcinoma, steroids or HIV infection|
|Fever, night sweats, weight loss|
|Widespread neurological symptoms especially sphincter disturbance|
|Structural spinal deformity|
The examination of a patient with lower back pain will focus primarily on the back but should also include:
- Neurological Examination
- Sacral Dermatomes (To assesses for herniation at the L4-S1 nerve roots)
- Nerve Roots with Knee Jerk and Ankle Jerk Tendon Reflexes
- Ability to straight leg raise
- Observations: heart rate, blood pressure, pulse oximetry and temperature
Each muscle is normally supplied by more than one nerve root, though one nerve root may be dominant. The muscles to be tested for each nerve root are shown in Table 2:
Table 2: Myotomes in the lower limb
|L4||Ankle dorsiflexionBig toe dorsiflexion|
|S1||Ankle plantar flexion|
If the patient has any loss of sensation or parasthaesiae, it is important to determine whether these are confined to one dermatome or whether they have a different (e.g. stocking) distribution. It is important to test sensation within each dermatome. These are shown in Fig 1:
Fig 1: Dermatomes in the lower limb
The neurological examination finishes with examination of the tendon reflexes. The nerve roots associated with each reflex are shown in Table 3:
Table 3: Nerve roots involved in the tendon reflexes
|Knee jerk||L3, L4|
|Ankle jerk||S1, S2|
While the patient is lying on their back for the neurological examination, it is a good time to test for the ability to straight leg raise. Many patients with back pain will have pain radiating to the buttock or leg but in true sciatica (the commonest nerve root lesions are L5 and S1), the pain radiates below the ankle. Some patients with nerve root problems only have pain in the leg and do not have back pain. Patients will have pain if the sciatic nerve is stretched. This occurs on straight leg raising. Dorsiflexion of the foot while the leg is raised will exacerbate the pain (sciatic stretch test).
In a nerve root lesion the patient will have parasthaesiae localised to the dermatome of the involved nerve root and will have altered sensation in the same dermatome. There will be muscle weakness in the corresponding myotome. Muscle weakness on one side with sensory changes on the other side or dissociated sensory changes (e.g. loss of light touch on one side and pain sensation on the other side) are serious signs indicating involvement of the spinal cord rather than a nerve root.
An L4/5 disc prolapse will tend to cause pressure on the L5 nerve root and an L5/S1 prolapse will cause pressure on the S1 nerve root.
It is essential to do a rectal examination and specifically test the sacral dermatomes sensation to assess for herniation at the L4-S1 nerve roots.
Consent the patient for a rectal examination, examine for rectal tone and the ability to contract the anal sphincter. Whilst performing the exam note any constipation or prostate enlargement (carcinoma of the prostate frequently metastasises to bone and may be a cause of back pain.)
Enquire about urinary symptoms as retention of urine or incontinence may indicate a central disc lesion.
With the patient lying on their side, test for sensation in the sacral dermatomes shown in Figure 2:
Fig 2: Sacral dermatomes
Some of the numerous causes of back pain are listed in Table 4. The most important issue for emergency physicians is to be able to differentiate serious from less serious causes and, in particular, to be able to recognise cauda equina compression.
Table 4: Causes of low back pain 
|Referred pain to spine from||
Cauda equina syndrome
Symptoms and signs of a cauda equina syndrome are:
- Acute low back pain (which may be superimposed on a history of chronic back problems)
- Radiation of pain to the legs (usually, but not always, bilateral)
- Lower limb weakness (frequently bilateral)
- Alteration of sacral and perineal sensation (usually, but not always, bilateral)
- Alteration of bladder and/or bowel habit leading to urinary retention and constipation
Not all patients will have all signs: the most sensitive are low back pain, perineal and sacral sensory loss and bladder disturbance . It is possible to have bladder dysfunction in the presence of intact anal tone. It may be missed if it is not considered and examined for and this is most likely to occur in the patient who walks into the department. Have a low threshold for requesting an MRI. A cauda equina syndrome (or spinal cord compression) is a surgical emergency that needs to be operated on within 24 hours after the onset of bladder symptoms. By the time the patient gets to the ED, bladder symptoms may have been present for many hours.
Non traumatic compression fractures
In women older than 50 years of age, the lifetime risk of vertebral fracture is estimated to be about one in three (including asymptomatic fractures). It may be very difficult (or even impossible) to date a fracture on X-ray especially as a previous fracture may have been asymptomatic; if there is no significant past history and the patient presents with acute back pain, it seems reasonable to assume the fracture is new / recent .
Postmenopausal women with an initial fracture are at much greater risk of subsequent fractures .
Other things that should be considered in patients with compression fractures but no history of trauma are metastases and multiple myeloma.
Spondylolisthesis is a forward slippage of one vertebra on another. The most common sites are a spondylolisthesis of L5 on S1 and L4 on L5.
The usual cause of the L5/S1 spondylolisthesis is a defect of the pars inter-articularis of L5 which allows slippage of the body of L5. This may be congenital or traumatic and tends to occur in young people.
Slippage of L4 on L5 is usually degenerative.
Spondylolisthesis may sometimes be seen as an incidental finding and so its presence in a patient with back pain does not necessarily mean that it is the cause of the pain. A CT may be helpful in determining the exact cause of the spondylolisthesis and its age.
Spinal infection, including tuberculosis (TB) is an uncommon cause of back pain but must be considered. Bone and joint TB accounts for about 1015% of non-respiratory tuberculous disease, and about half of this is in the spine. Spinal TB must, particularly, be considered in ethnic minority groups. The most common presenting symptom is back pain and there may be spinal tenderness and kyphosis. It may present with a paraspinal abscess as loin swelling or as a psoas abscess with spasm and hip flexion. Neurological symptoms can occur. Systemic symptoms such as weight loss and night sweats can occur but is not common in bony TB. There is no evidence to preferentially recommend CT or MR scanning for these patients .
Patients with a history of malignancy may have non-specific back pain but metastasis should always be considered. The following symptoms and signs are suggestive of this:
- pain in the middle (thoracic) or upper (cervical) spine
- progressive lower (lumbar) spinal pain
- severe unremitting lower spinal pain
- spinal pain aggravated by straining (for example, at stool, or when coughing or sneezing)
- localised spinal tenderness
- nocturnal spinal pain preventing sleep
The investigation of choice is an MRI rather than plain X-rays.
No investigation is required for the vast majority of patients with non-specific back pain. Red flag symptoms or signs suggestive of cauda equina syndrome will mandate urgent MRI scanning.
Imaging of patients with non-specific back pain and no red flag symptoms or signs is unhelpful. Many patients with spinal pathology may have normal plain X-rays and, conversely, many patients with no back pain may have X-ray abnormalities (particularly degenerative disease). Similarly many patients with no back pain have abnormal MRI scans.
Blood tests may be useful if one suspects infection or metabolic problems but are not necessary as screening investigations for patients with no pointers to those problems.
In primary care, radiography of the lumbar spine in patients with back pain of more than six weeks duration improved patient satisfaction but did not improve outcome . There is no published evidence on the value of X-rays in the acute setting but the inference is that there is no benefit .
Symptomatic treatment of acute musculoskeletal lower back pain
Analgesia. Patients in pain should be given analgesia. The Cochrane Collaboration found that non-steroidal anti-inflammatory drugs (NSAIDs) are slightly more effective for short term symptomatic relief in patients with acute back pain (without sciatica) when compared with placebo. However they comment than many of the studies are of poor quality and there are few data on long term results and side effects . A further review found them to be valuable .
Muscle relaxants. Muscle relaxants are effective in the management of non-specific low back pain, but the adverse effects require that they be used with caution [12,13].
Patients should be advised to stay active. Although many people get some relief from low back pain by lying down, advice to rest in bed is less effective in reducing pain and improving an individuals ability to perform every day activities than advice to stay active [14,15].
Physiotherapy. While it has been argued that physiotherapy is of little value in back pain , the trial to which the author refers  compared routine physiotherapy with an assessment session and advice from a physiotherapist. A physiotherapist assessing and advising a patient is likely to spend much more time doing so than a doctor in the ED so this trial cannot say that referral to a physiotherapist is of no value. Another study has shown that manipulation followed by exercise was of benefit . There is great diversity of patients in many of the trials and equal diversity among physiotherapists and the treatments they offer and so it is difficult to conclude definitively on the value of physiotherapy for any individual patient.
Other treatments that have been investigated for low back pain are:
- Traction. Studies have shown that traction (continuous or intermittent) as a single treatment for LBP was no more effective than placebo 
- Massage. While massage is of value for chronic back pain, there is still not enough evidence about massage for acute back pain[20,21]
- Antidepressants. Antidepressants are a common treatment for low-back pain. They are prescribed for three main reasons: to provide pain relief, help with sleep and reduce depression. However a Cochrane review could find no convincing evidence that antidepressants relieve back pain or depression more effectively than placebo. They did not result in any other apparent benefits in the treatment of back pain and they had side effects . They may have a role in neurological pain in sciatica
- Local heat. There is moderate evidence that heat wrap therapy reduces pain and disability for patients with back pain that lasts for less than three months. The relief has only been shown to occur for a short time and the effect is relatively small. The addition of exercise to heat wrap therapy appears to provide additional benefit 
- Local cold. There is still not enough evidence about the effect of the application of cold for low-back pain of any duration 
- Individual patient education for low back pain. People with low-back pain who received an in-person patient education session lasting at least two hours in addition to their usual care had better outcomes than people who only received usual care. Shorter education sessions, or providing written information by itself without an in-person education session, did not seem to be effective 
- Spinal manipulative therapy. Spinal manipulation was more effective in reducing pain and improving the ability to perform everyday activities than sham therapy and therapies already known to be unhelpful. However, it was no more or less effective than medication for pain, physical therapy, exercises, back school or the care given by a general practitioner 
- Exercise therapy. In acute low-back pain, exercise therapy has not been shown to improve pain or function over no treatment or other conservative treatments. However it appears to be slightly effective at decreasing pain and improving function in adults with chronic low-back pain, particularly in healthcare populations. In subacute low-back pain there is some evidence that a graded activity program improves absenteeism outcomes, though evidence for other types of exercise is unclear [26,27]
- Lumbar supports. It is unclear whether lumbar supports are more effective than no or other interventions for treating low-back pain 
- Acupuncture. There is no evidence to support the use of this 
- Strong opiates (eg oramorph). There are no published trials looking at this 
Note that the above evidence largely relates to acute back pain. The results for chronic and subacute back pain may be different.
Treatment of Cauda Equina Syndrome
Cauda equina syndrome is a neurosurgical emergency and urgent referral by the emergency physician will be required once the diagnosis has been made on MRI scanning.
Treatment of sciatica
Epidural injection therapy is commonly used, relatively straightforward and safe. However its value has not been proven . There is a suggestion that it may be of benefit to some patients with sciatica but most of the studies have been in patients with subacute or chronic pain.
Trials of surgery provide suggestive rather than conclusive results. Overall, surgical discectomy for carefully selected patients with sciatica due to a prolapsed lumbar disc appears to provide faster relief from the acute attack than non-surgical management. However, any positive or negative effects on the lifetime natural history of the underlying disc disease are unclear. Microdiscectomy gives broadly comparable results to standard discectomy. There is insufficient evidence on other surgical techniques to draw firm conclusions. Trials showed that discectomy produced better outcomes than chemonucleolysis, which in turn was better than placebo. For various reasons including concerns about safety, chemonucleolysis is not commonly used today to treat prolapsed disc .
A recent study has shown that discectomy gives more rapid relief of leg pain than conservative treatment and earlier return to normal activities but the differences between the groups were not statistically different by six months. There was no significant difference in back pain and surgery did not decrease the risk of an unsatisfactory outcome at two years. However 44% of patients allocated to the conservative arm of the trial eventually required surgery .
Treatment of vertebral compression fractures
Conventional treatment for vertebral compression fractures is not evidence-based and is focused on the alleviation of symptoms with analgesia medication. Spinal support may help the pain but patients also need to mobilize to regain back movement. The majority of patients become symptom free through these measures. Patients who continue to have pain should be followed up and have repeat lateral standing lumbar spine X-rays to ensure that they are not developing progressive deformity. Surgery may be considered in patients in whom there is continued vertebral collapse and severe pain. Patients with continuing severe pain may also be helped by less invasive procedures, including balloon kyphoplasty [34,35].
Osteoporosis will also need to be investigated and managed. Postmenopausal women with an initial fracture are at much greater risk of subsequent fractures  so this is very important and may help to prevent a future attendance with a hip fracture.
Treatment of metastatic disease
Patients with bone metastases and patients at high risk of developing bone metastases should be given information explaining what to do and who to contact if they develop symptoms of spinal metastases or spinal cord compression or if their symptoms progress while waiting for investigation.
Spinal cord compression is an oncological emergency and treatment should be started within 24 hours. Most patients will be given steroids and will need radiotherapy or surgery. Patients with a risk of spinal instability should be nursed flat in neutral alignment.
NICE has recommended (for England and Wales) that every center should have a coordinator for patients with spinal metastases and metastatic spinal cord compression, to whom such patients should be referred .
Follow up (if required) is not the role of the emergency physician but may be required by general practitioners, orthopaedic surgeons, spinal surgeons, geriatricians or rehabilitation teams. It is not possible to be prescriptive other than to say that it is the emergency physicians responsibility to recognise when follow-up is appropriate and make the necessary referral.
Prognosis clearly depends on the underlying cause of the back pain but for non-specific musculoskeletal pain, the prognosis is good.
One study has shown that following an episode of back pain 67% had returned to work within seven days and 84% within a month. However 70% have some pain on returning to work . A systematic review has shown very similar figures: pain and disability decrease rapidly within a month (by a mean of 58% of initial levels) and continue to improve until about three months. 82% (95%CI 73-91%) return to work within a month and 93% (91-96%) within three months and a proportion have some of pain extending beyond three months. There is a 26% (19-34%) chance of recurrence within three months and 73% (59-88%) chance of recurrence within a year .
Predictors of a poor outcome (in a primary care study)  include:
- Increasing age
- Female gender
- Previous history of back pain
- High levels of psychological distress
- Poor self-rated health
- Dissatisfaction with employment
Factors relating to back pain:
- Duration of symptoms
- Pain radiating to the leg
- Widespread pain
- Restriction in spinal mobility
Patients with sciatica return to work more slowly than those with acute back pain without sciatica but exact figures are not available .
- In any patient with back pain and urinary symptoms, consider cauda equina syndrome (though the absence of such symptoms does not exclude the diagnosis)
- Beware of back pain that does not sound musculoskeletal (e.g. it is not affected by movement or position). This may suggest sepsis, malignancy or an intra-abdominal cause for the pain (e.g. ruptured abdominal aortic aneurism (AAA) or retroperitoneal bowel perforation).
- Clinical Standards Advisory Group Committee on Back Pain (Chair Rosen M). Back pain 1994 Pub HMSO London.
- The Epidemiology and Cost of Back Pain. Annex to the Clinical Standards Advisory Groups Report on Back Pain (Chair Rosen M). Back pain 1994 Pub HMSO London.
- Speed C. ABC of rheumatology: low back pain Br Med J 2004;328:1119-21.
- Koes BW, van Tulder MW, Thomas S. Diagnosis and treatment of low back pain. Br Med J 2006;332:1430-4.
- Jalloh I, Minhas P. Delays in the treatment of cauda equina syndrome due to its variable clinical features in patients presenting to the emergency department. Emerg Med J 2007;24:33-4.
- NICE. Bisphosphonates (alendronate, etidronate, risedronate), selective oestrogen receptor modulators (raloxifene) and parathyroid hormone (teriparatide) for the secondary prevention of osteoporotic fragility fractures in postmenopausal women. Pub National Institute for Clinical Excellence 2005. View document
- Royal College of Physicians of London. Tuberculosis: Clinical diagnosis and management of tuberculosis, and measures for its prevention and control. Pub NICE 2006. View document
- Kendrick D, Fielding K, Bentley E, Kerslake R, Miller P, Pringle M. Radiography of the lumbar spine in primary care patients with low back pain; randomised controlled trial. Br Med J 2001;322:400-5.
- Carley S. Early radiography in acute lower back pain. View topic
- Roelofs PDDM, Deyo RA, Koes BW, Scholten RJPM, van Tulder MW. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD000396. DOI: 10.1002/14651858.CD000396.pub3 View abstract
- Carley S. NSAIDS in acute low back pain. View topic
- van Tulder MW, Touray T, Furlan AD, Solway S, Bouter LM. Muscle relaxants for non-specific low-back pain.Cochrane Database of Systematic Reviews 2003, Issue 3. Art. No.: CD004252. DOI: 10.1002/14651858.CD004252.View abstract
- Carley S. Muscle relaxants for acute low back pain. View topic
- Hagen KB, Hilde G, Jamtvedt G, Winnem M. Bed rest for acute low-back pain and sciatica. Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.: CD001254. DOI: 10.1002/14651858.CD001254.pub2 View abstract
- Carley S. Bed rest for acute simple lower back pain. View topic
- MacAuley D. Back pain and physiotherapy. Br med J 2004;329:694-5.
- Frost H, Lamb SE, Doll HA, Carver PT, Stewart-Brown S. Randomised controlled trial of physiotherapy compared with advice for low back pain. Br Med J 2004;329:708-11.
- UK BEAM Trial Team. United Kingdom back pain exercise and manipulation (UK BEAM) randomised trial: effectiveness of physical treatments for back pain in primary care. Br med J. 2004;3291377-81.
- Clarke JA, van Tulder MW, Blomberg SEI, de Vet HCW, van der Heijden GJMG, Bronfort G, Bouter LM. Traction for low-back pain with or without sciatica. Cochrane Database of Systematic Reviews 2007, Issue 1. Art. No.: CD003010. DOI: 10.1002/14651858.CD003010.pub4. View abstract
- Furlan AD, Brosseau L, Imamura M, Irvin E. Massage for low-back pain. Cochrane Database of Systematic Reviews2002, Issue 1. Art. No.: CD001929. DOI: 10.1002/14651858.CD001929. View abstract
- Carley S. Massage therapy for acute low back pain. View topic
- Urquhart DM, Hoving JL, Assendelft WWJJ, Roland M, van Tulder MW. Antidepressants for non-specific low back pain. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD001703. DOI: 10.1002/14651858.CD001703.pub3. View abstract
- French SD, Cameron M, Walker BF, Reggars JW, Esterman AJ. Superficial heat or cold for low back pain. Cochrane Database of Systematic Reviews 2006, Issue 1. Art. No.: CD004750. DOI: 10.1002/14651858.CD004750.pub2. View abstract
- Engers A, Jellema P, Wensing M, van der Windt DAWM, Grol R, van Tulder MW.. Individual patient education for low back pain. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD004057. DOI: 10.1002/14651858.CD004057.pub3. View abstract
- Assendelft WJJ, Morton SC, Yu Emily I, Suttorp MJ, Shekelle PG. Spinal manipulative therapy for low-back pain.Cochrane Database of Systematic Reviews 2004, Issue 1. Art. No.: CD000447. DOI: 10.1002/14651858.CD000447.pub2. View abstract
- Hayden JA, van Tulder MW, Malmivaara A, Koes BW.. Exercise therapy for treatment of non-specific low back pain.Cochrane Database of Systematic Reviews 2005, Issue 2. Art. No.: CD000335. DOI: 10.1002/14651858.CD000335.pub2. View abstract
- Carley S. Exercise for acute back pain. View topic
- Van Duijvenbode ICD, Jellema P, van Poppel MNM, van Tulder MW. Lumbar supports for prevention and treatment of low back pain. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD001823. DOI: 10.1002/14651858.CD001823.pub3. View abstract
- Carley S. Acupuncture in acute back pain. View topic
- Carley S. Strong opiates in the treatment of acute low back pain. View topic
- Staal JB, de Bie R, de Vet HCW, Hildebrandt J, Nelemans P. Injection therapy for subacute and chronic low-back pain. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD001824. DOI: 10.1002/14651858.CD001824.pub3. View abstract
- Gibson JNA, Waddell G.. Surgical interventions for lumbar disc prolapse. Cochrane Database of Systematic Reviews2007, Issue 1. Art. No.: CD001350. DOI: 10.1002/14651858.CD001350.pub4. View abstract
- Peul WC, van den Hout WB, Brand R, Thomeer RTWM, Koes BW. Prolonged conservative care versus early surgery in patients with sciatica caused by lumbar disc herniation: two year results of a randomised controlled trial. Br Med J 2008;336:1355-8.
- NICE. Balloon vertebroplasty for vertebral compression fracture. Pub National Institute for clinical Excellence, 2006.View document
- NICE. Percutaneous vertebroplasty. Pub National Institute for clinical Excellence, 2003. View document
- Pengel LHM, Herbert RD, Maher CG, Refshauge KM. Acute low back pain; systematic review of its prognosis. Br Med J. 2003;327:323-5.
- Thomas E, Silman AJ, Papageorgiou AC, Jayson MIV, MacFarlane GJ. Predicting who develops chronic low back pain in primary care: a prospective study. Br Med J 1999;318:1662-7.
- NICE. Metastatic spinal cord compression. Diagnosis and management of adults and risk of and with metastatic spinal cord compression. Pub NICE 2008. View document
Two further important documents:
- Lavy C, James A, Wilson-McDonald J, Fairbank J. Cauda equina syndrome. Br Med J. 2009;338:881-4.
- Low back pain: Early management of persistent non-specific low back pain Pub NICE 2009. View document