This session is about assessment and management of patients presenting with palpitations to the emergency department.
Context and definition
The term palpitations is defined as the sensation in which a person is aware of an irregular, hard, or rapid heartbeat.
The presenting complaint of palpitations is one of the more frequently encountered reasons for attendance to the Emergency Department (ED) and the second commonest cardiac related presentation  .The majority of patients with palpitations have a very good prognosis the challenge for the emergency physician is to identify the minority of patients who have significant cardiac dysrhythmia or underlying disease.
The symptom of palpitations has varying meaning to patients and clarity must me sought. They are commonly described as an increased awareness of ones own heartbeat but also cover a sensation of fast or irregular heart beat or excessive pulsation. A key factor in patients deciding to seek medical advice is that this subjective awareness of cardiac activity is an unpleasant or distressing sensation.
Any arrhythmia may cause palpitations, however it is more likely to be as a result of a tachyarrhythmia rather than bradyarrhythmia. The mechanism by which a patient becomes aware of cardiac contractions is unclear as the usual physiological state is a filtering of afferent feedback rendering the sensation of cardiac activity to the subconsciousness. A change of rate, rhythm and contractility may alter this, bringing this afferent activity to the conscious level. It is clear that this is a variable response, demonstrated by the number of patients found to be in an arrhythmia without any symptoms: in the Framingham Study the age adjusted prevalence of asymptomatic frequent or complex arrhythmia was 12% in men without coronary disease and 33% in those with coronary disease .
The causes of palpitations are numerous but can be broadly split into cardiac and non-cardiac causes (see Table 1).
Table 1: The Causes of Palpitations
|Sinus arrythmia||Sinus tachycardia||Sypathomimetics||Anaemia||Anxiety disorder|
|Atrial fibrillation||Congenital structural disease||Cardiac drugs||Metabolic disorder||Somatisation|
|Atrial flutter||Acquired valvular disease||Illicit drugs||Pyrexia|
|Heart block (AVB)||Heart failure||Alcohol||Hypovolaemia|
|VT||Myocarditis||Serotoninergic drugs||Pulmonary disease|
|Pre-excitation (WPW)||Sodium channel blockers||Hypoxia|
|PVC||Therapeutic drug withdrawal|
In a study of 190 patients a cardiac aetiology was found in 43% of patients (40% had an arrhythmia and 3% other non-arrhythmic cardiac causes). Non-cardiac causes were diagnosed in 41% (anxiety was diagnosed in 31%, drugs and toxic causes in 6%, and 4% other non-cardiac causes). In total a specific aetiology was attributed in 84% of the patients in the study.2AVB = Atrioventricular block; SVT = Supraventricular tachycardia; VT = Ventricular tachycardia; WPW = Wolf Parkinson White Syndrome; PVC = Premature ventricular contractions
Palpitations have an underlying cardiac cause in 43%, are due to anxiety in 31% and have no specific attributable cause in 16% of patients.
The overall prognosis for patients with palpitations is very good; this reflects that the commonest finding of ambulatory monitoring is either benign ventricular or atrial ectopic beats3. However, palpitations may indicate significant structural disease or arrhythmia and should prompt careful consideration of risk in the individual.
Mortality in specific arrhythmias does depend on the underlying rhythm. In the Framingham study, men without coronary heart disease who demonstrated frequent or complex arrhythmias had an increased relative risk of all cause mortality (RR 2.3 CI 1.65-3.2).1
Notwithstanding specific aetiology, the absolute risk of death is low: a study of 190 patients revealed a one year risk of death of 1.3% and stroke of 1.1%.2
Given the wide range of causes of palpitations (see Table 1) a detailed history and systemic enquiry is required. Full details of previous medical problems, medications and social drug use are required. A systematic and focused history (see below) will help to establish the nature, consequences and cause of an individuals palpitations:
(i) Establish the exact nature of the palpitations including:
- Missed Beat Sensation
- Extra Beat Sensation
- Precipitating factors (including dietary, posture, exercise and sleep)
- Relieving factors
(ii) Establish the presence of adverse clinical features associated with the presence of palpitations:
- Chest pain
- Extreme fatigue
(iii) Establish the presence of symptoms which may indicate an underlying cause:
- Chest pain (in the absence of or preceding palpitations)
- Abdominal pain
- Heat intolerance
- Weight change
- Productive cough
Past medical, drug and social history:
Previous medical history must include checking for a history of structural heart disease and a family history of sudden cardiac death should be enquired for (if known) particularly in first degree relatives.
Drug history must obviously be detailed as many prescription and over-the-counter medicines have cardiac effects. Included in this should be a specific enquiry about herbal and other alternative treatments as some of these contain surprising amounts of stimulants such as caffeine.
Social history must detail alcohol and illicit drug use.
Factors associated with a significant underlying arrythmia
A 2009 literature review4 identified only three findings in patients presenting with palpitations which were associated with a likelihood ratio of 2.00 or greater for a significant arrhythmia:
(i) a previous history of cardiac disease
(ii) palpitations whilst sleeping
(iii) palpitations at work
Two factors associated with a likelihood ratio of 0.5 or less of significant arrhythmia were an underlying anxiety disorder and palpitations lasting less than 5 minutes.
Male sex, irregular heartbeat, history of cardiac disease and a duration of greater than 5 minutes predicted a cardiac aetiology in the study by Weber and Kapoor.1 In further studies evaluating presenting features of patients with palpitations, male and older patients were found more likely to have an arrhythmic aetiology whereas a psychosomatic cause was more likely in female and younger patients. 
Physical examination must be detailed enough to identify the numerous aetiologies listed in Table 1.
A thorough cardiovascular examination is essential with evaluation of the rate and rhythm of the pulse, careful auscultation of the heart and assessment for signs of heart failure. Features suggestive of cardiovascular or respiratory compromise must be elicited (ie. hypoxia or hypotension); these may be a cause or a consequence of the underlying pathology related to palpitations.
Rarer signs of palpitations and their origin:
- Murmurs, altered apex beat
- HCM that gives a double apex beat and an ejection systolic murmur
- Cardiovascular collapse
It is important to evaluate for systemic signs of illness including the presence of pyrexia, pallor (anaemia), metabolic disturbance (eg. thyrotoxic features), and alcohol or drug intoxication.
A brief psychological assessment is also appropriate to detect the presence of heightened anxiety.
12 Lead Electrocardiogram:
Twelve lead ECG recording is clearly the primary diagnostic test and if temporally correlated with symptoms of palpitations this will have a very high yield revealing the presence or absence of an underlying arrhythmia; if this is the case, a confident diagnosis can be made.
In the absence of the patient actually having palpitations at the time that the ECG is recorded, the trace must be examined closely for the following:
- Pre-excitation e.g. Wolf Parkinson White Syndrome (see Figure 1)
- P Wave abnormalities
- Left ventricular hypertrophy
- Abnormal QRST morphology e.g. Brugada syndrome (see Figure 2)
- Frequent ventricular premature beats
- Q waves
- Abnormal QT duration (long and short)
- Atrioventricular block (see Figure 3)
- Fascicular block
Any of these abnormalities may indicate a potential underlying aetiology for the presenting symptoms: Pre-excitation may indicate recurrent SVT, prolonged QT interval and findings suggestive of Brugada Syndrome may herald recurrent VT, atrioventricular block may produce symptomatic bradyarrhythmias, etc.
Carefull examination of the resting ECG, even in the absence of symptoms, may reveal the underlying cause of a patients palpitations.
Figure 1: Pre-excitation note the short PR interval and the slurred upstroke of the R wave
Figure 2: Brugada Syndrome note down-sloping ST segment elevation in leads V1 and V2
Figure 3: Atrioventricular block Second degree heart block (Mobitz type 2) with 2:1 block
In addition to the 12 lead ECG the following ED-based investigations are required to further evaluate underlying causes for palpitations where clinical examination is suggestive of a particular underlying disorder (eg. metabolic derangement, anaemia, thyrotoxicosis, etc.):
- Electrolyte measurement (potassium, calcium and magnesium)
- Bedside glucose measurement
- Thyroid function tests
- Full blood count
Management in the Emergency Department
(i) Is intervention required?
The patient may be displaying an arrhythmia on ECG monitoring at the time of assessment. If this is the case manage the arrhythmia as per current guidelines. In the case of the haemodynamically compromised patient resuscitation and emergency management as per Advanced Life Support should be provided.
Where a specific underlying cause has been identified for a patients palpitations (either cardiac or non-cardiac), management will be determined by the specific causal pathology.
(ii) Is admission required?
In asymptomatic patients without demonstrable arrhythmia the immediate challenge is to identify those who require emergency admission for diagnostic purposes and subsequent treatment.
Risk stratification is required to identify patients who are at a higher risk of an adverse event for whom admission is necessary the following features will identify these patients:
- Patients who are at imminent risk of life threatening arrhythmia e.g. those with a previously recorded episode of VT
- Patients who had adverse symptoms or signs during the palpitations.
- Patients with implanted cardiac devices suspected of malfunction.
- Patients with a family history of sudden death (eg, Brugada Syndrome).
- Patients who require admission for investigation or treatment of an underlying cause or precipitating illness, for example acute coronary syndrome, electrolyte disturbance or endocrine disorder.
Patients for whom admission is not necessary will fall into two groups:
(i) those for whom an innocent diagnosis is confidently achieved (either cardiac or non-cardiac) and
(ii) those whose symptoms have resolved and in whom no specific aetiology has been demonstrated and they have none of the high risk features above.
Careful risk stratification is required to determine which patients require urgent admission for further investigation and management.
(iii) Is further investigation required if a diagnosis is not made?
Patients with a suspected arrhythmia (eg. pre-excitation on their ECG) or structural heart disease (eg. a murmur on auscultation) but without high risk features mandating admission will require referral to cardiology for follow-up, further investigation and management.
For those in whom a specific diagnosis is not made or suspected in the ED, subsequent investigation will vary depending on the frequency and nature of symptoms. Methods of ambulatory monitoring will vary from 24 hour recording to more long term event monitors. Selection will depend on the exact nature of the palpitations. Daily palpitations, for example, will be recorded by a 24 hour Holter monitor but palpitations that are very infrequent yet produce adverse clinical features may warrant an implanted recording device to determine the underlying rhythm.
Local access to investigation and follow up will vary and there may be established protocols for investigation. For the emergency physician there are likely to be three options:
- Referral back to the patients general practitioner for follow up and discretionary cardiology referral. This would be suitable for low risk patients who report occasional missed beats.
- Referral directly to cardiology for out-patient follow-up.
- Referral for ambulatory monitoring +/- echocadiography and subsequent cardiology follow up.
In patients where structural heart disease is suspected then it is appropriate to arrange an outpatient echocardiogram directly.
Advice on Discharge:
Patients discharged from the ED pending general practice or cardiology follow up should be given advice with regards to future episodes. Patients should avoid stimulants such as caffeine, alcohol and nicotine. It is useful to keep a record of episodes and any associated symptoms. If the palpitations recur patients should attend the ED if they are persistent or are associated with adverse features. Finally it may be useful to ask patients to attempt to terminate suspected SVT for example by teaching them one of the variants of the Valsalva maneuver.
Anyone with concerning cause of palpitations should be advised to exercise at a light/moderate intensity (i.e without getting short of breath), until review by cardiology.
- Overall prognosis for patients with palpitations is very good with most being of a benign aetiology.
- Approximately 43% of patients have a cardiac cause for their palpitations.
- Anxiety is diagnosed in nearly a third of patients presenting with palpitations.
- There is a very wide range of aetiologies, both cardiac and non-cardiac.
- Patients at risk of serious adverse events require admission.
- Patients with suspected arrhythmia or structural heart disease require referral for cardiology follow up.
- Low risk patients can be referred back to their general practitioner for follow up.
- Bikkina M, Larson MG, Levy D. Prognostic implications of asymptomatic ventricular arrhythmias: The Framingham Heart Study. Ann Intern Med.1992;117(12):1053-4.
- Weber BE, Kapoor WN. Evaluation and outcomes of patients with palpitations. Am J Med. 1996;100(2):138-148.
- Abbott A. Diagnostic Approach to Palpitations Am Fam Physician. 2005 Feb 15;71(4):743-750.
- Paaladinesh Thavendiranathan, Akshay Bagai, Clarence Khoo et al. Does This Patient With Palpitations Have a Cardiac Arrhythmia? JAMA. 2009;302(19):2135-2143
- Antonio Raviele, Franco Giada, Lennart Bergfeldt et al. Management of Patients With Palpitations: A Position Paper From the European Heart Rhythm Association. Europace. 2011;13(7):920-934.
- NICE CKS. Palpitations. 2015.
- Pitcher, D. Nolan, J. Peri-arrest arrhythmias. Resuscitation Council guidelines (arrhythmias). 2015.
- BMJ. Assessment of Palpitations. 2016.