Author: Christopher Connolly, Katherine Rankin / Editor: Jonathan D Whittaker / Reviewer: Louise Burrows / Codes: HAP9 / Published: 17/07/2017 / Review Date: 17/07/2020
There is extremely wide geographical variation in the organisation of out-of-hours dental services provided in the United Kingdom. In many parts of the UK there are no formal out-of-hours care arrangements for unregistered patients, even at weekends.
One study has shown that on weekday nights over two-thirds of UK health authorities have no formal arrangements for unregistered patients. At the weekend just under half have separate arrangements for registered and unregistered patients, and one fifth have no formal dental care arrangement at all 1.
It is little wonder in this confusing time, patients with dental emergencies attend the Emergency Department, as they feel they have nowhere else to turn. In fact presentations of non-traumatic dental problems can account for between 0.3 and 0.5% of ED attendances 2.
A recent study has shown that while junior doctors in the ED are seeing dental problems on an almost weekly basis, up to half of juniors have had no formal training in examination of the mouth, are unable to identify the timings of deciduous and permanent teeth eruptions and only 29% could describe the optimal management of a dental infection 3.
Although dental problems are a common presentation, junior doctors in the ED have inadequate knowledge and are poorly prepared to deal with the most common problems encountered.
The adult human has 32 permanent teeth divided as (anterior to posterior) incisor, canine, pre-molar and molars. We are not born with this number nor do our original teeth remain for long past childhood.
Deciduous, or milk, teeth erupt throughout childhood, incisors aged 6-10 months, canine teeth aged 16-20 months, and molars aged 10-24 months. Permanent replacements for these teeth erupt again at a range of ages, as a rough guide; incisors aged 7-8 years, canine and premolars age 11-13 years, and molars aged 6 -25 years (including those born with wisdom teeth 3rd molars).
The gross anatomy and orientation of the permanent teeth
Each tooth can be simply divided into crown and root, the clinical crown being that part of the tooth which is visible within the mouth and the root being that which is not. The majority of the crown is composed of dentine surrounded by enamel with an inner pulp chamber; the root is also composed mainly of dentine with pulp channels within. The pulp contains the neurovascular structures of the tooth, and it is here where dental pain originates.
The surface of the tooth responsible for the chewing or cutting of food is known as the occlusal surface, these surfaces often contain elevations known as cusps, contributing a significant proportion of the tooths surface.
The teeth are maintained within the mandible and maxilla by the periodontium, this is comprised of four tissues, alveolar bone, cementum, gingiva and the periodontal ligament (PDL). The alveolar bone is the thickened ridge of bone that contains the tooth sockets. The PDL attaches the tooth to the alveolar bone in which it sits. The PDL has a role in the stabilisation of the tooth during chewing and also has propioceptive properties.
The gums (gingiva) are composed of dense fibrous tissue, closely connected to the periosteum of the alveolar processes, and surrounding the necks of the teeth.
The basic composition of a tooth and its surrounding structures
Pathophysiology of Dental Infection
Acute dental abscess usually occurs secondary to dental caries or following a dental procedure or trauma. The most common cause, dental caries, is caused by erosion of enamel by acids produced as a by-product of fermentation of dietary carbohydrates by normal bacterial flora. This introduces bacteria into the tooth, which spreads firstly into the pulp then to the root and local tissues. Infection then may spread superficially into the tissues producing gingivitis or a dental abscess. Very occasionally infection spreads to the deep facial planes forming a retropharyngeal abscess or Ludwigs angina.
Dental abscess is usually polymicrobial with numerous pathogen combinations being recognised, common pathogens include Streptococcus sp. Along with Staphylococcus sp, Staph.aureus has been isolated in up to 15% of abscess cultures with the most common anaerobic species being Prevotella sp (1087 % of dentoalveolar abscesses) 4.
Dental infection most commonly arises from the process of dental caries and is usually polymicrobial with both aerobic and anaerobic bacteria being responsible.
In the busy environment of the ED history taking needs to be concise and focused, giving opportunity to highlight worrying features. Below are the salient points that should be included in the history.
- When did the symptoms start?
- Have antibiotics already been taken? a worsening condition in a patient already taking antibiotics is concerning.
- Has the patient seen a dentist? most causes of mouth infection need definitive treatment by dealing with the cause in general, ED care is a temporising measure only.
- Is the patient systemically unwell? this indicates potential spread of the infection beyond the tooth and gum.
- Is the patient immunocompromised? e.g. diabetes, HIV, steroid use or general poor health.
- Have you considered non-dental causes of tooth pain ?
|Trauma||Referred sinus pain|
|Gingivitis||Cardiac angina felt in jaw|
|Dental abscess||Trigeminal neuralgia|
|Cervicofacial space abscess||Referred ear pain|
|Ludwigs angina||Parotid inflammation and infection|
All pain in the mouth is not dental in origin. Be aware of radiation of pain from other areas, particularly the heart.
Examination of the mouth
The initial examination must include an ABC assessment as, rarely, dental infection may be complicated by airway obstruction. The presence of any of the following may indicate actual or impending airway compromise and should prompt an urgent senior anaesthetic assessment:
- Difficulty in breathing
- Dysphonia (alteration in the character of the voice)
Dental infections may be complicated by airway compromise and need urgent anaesthetic intervention.
A general examination and set of observations including temperature, blood pressure, pulse, respiratory rate and oxygen saturations will identify signs of systemic disturbance.
Examination of the face
- Is there visible swelling? if there is:
- Where is it?
- Cheek swelling is typically found in either upper or lower tooth abscess
- Submandibular swelling occurs in infection of the molars
- Is it firm or fluctuant? Fluctuant swelling indicates a collection of fluid usually pus.
- Does it extend into the neck? This may indicate spreading infection.
- Is there trismus (inability to open the mouth normally)?
- Are there any palpable lymph nodes present?
Examination of the mouth
For an adequate examination, it is essential to use a bright light, tongue depressor and mirror.
- Look at the teeth, what condition are they in? Are there any caries?
- Are the gums red , bleeding, inflamed or swollen?
- Look in the sublingual space for swelling and redness these are signs of sublingual infection and potential airway compromise
- Look at the pharynx is there evidence of swelling? this may indicate retropharyngeal spread of infection
- Feel in the mouth with a gloved finger for tenderness, swelling and/or fluctuance
Swelling of the pharynx or under the tongue are serious signs that indicate spread of infection into the deeper tissues.
Worrying Features in the History and Examination
During the course of the history and examination, the clinician may identify features that suggest a more serious problem. If any of these features are present consider seeking advice from a senior colleague, anaesthetist or maxillofacial specialist as appropriate.
|Systemic upset e.g. pyrexia, vomiting||Sublingual or pharyngeal swelling|
|Rapid progression of illness||Dyspnoea|
|Progression of illness despite current antibiotic treatment|
Blood tests are very rarely helpful in the diagnosis or treatment of dental infection unless the patient is immunocompromised or there are signs of significant systemic upset. For uncomplicated infections there is no role for blood tests in the ED.
The role of imaging in the ED is limited and not indicated for the investigation of most dental infections. If required it should only be requested following consultation with a maxillofacial specialist.
If spread to the retropharyngeal space is suspected, a soft tissue view of the neck may help to confirm the diagnosis.
Retropharyngeal infection arrows indicate air in the retropharyngeal tissues.
Investigations are of little use to the management of most dental infection in the ED. A thorough examination should provide all the information needed to treat these patients
The provision of analgesia in the ED simply serves as a temporising measure until the source of pain is treated i.e. a dental practitioner can be seen.
Once non-dental causes of pain have been ruled out, dental pain is managed by identification of the source of the pain and judicious use of analgesia. Non-steroidal anti-inflammatory drugs (NSAIDs) are the recommended first line analgesics for dental pain with ibuprofen being the drug of choice due to its low incidence of gastrointestinal side effects 5.
Paracetamol also has a role to play both as an analgesic and anti-pyretic, either in addition to a NSAID or when NSAIDs are contra-indicated.
Opiod analgesia is traditionally used in moderate and severe pain, however opiates are relatively ineffective when dealing with dental pain 6. Opiates should therefore be reserved for adjunctive analgesia in situations where paracetamol and NSAIDs have failed to achieve adequate pain relief.
The vast majority of patients with toothache presenting to the ED should be managed with simple analgesia and advice to attend a dental practitioner as soon as possible.
Paracetamol and ibuprofen
Dental Infection and Abscess
This is one of the most common dental problems presenting to the ED. Common symptoms and signs include pain, localised erythema, periodontal and facial swelling and direct tenderness to palpation of the responsible tooth.
Once appropriate analgesia has been administered the decision arises whether to prescribe a course of antibiotics. Considerable variation exists in practice as demonstrated by one study which found that antibiotic prescribing for dental problems varied greatly; 68% of patients attending a medical practitioner received antibiotics whereas antibiotics were only given to less than a third of patients attending a dentist 7.
The type of antibiotic prescribed also varies greatly; 90% of prescriptions in one study were for either amoxicillin, metronidazole orpenicillin V 8. Another study showed that combinations of antibiotics were used in nearly 6% of cases 9 despite guidance that combination antibiotics should be avoided if at all possible in dental infection 10.
Are antibiotics indicated in my patient?
National antibiotic prescribing guidance for dental problems 11,12 states that antimicrobials should be only given to patients with:
- Symptoms or signs of systemic illness
- High risk patients where complications are likely e.g. immunocompromised patients, diabetics
Antibiotics are generally not indicated for otherwise healthy individuals or when there no signs of spreading infection. They do not form the mainstay of treatment of local infection and early management of the source must be a priority.
Antibiotics should only be prescribed for dental abscess where there are signs of systemic infection or in patients who are at a high risk of complications.
Which antibiotic should be prescribed?
If prescribing an antibiotic, first line treatment is amoxicillin ormetronidazole for a total of 5 days. If, after 48 hrs, there is no improvement in systemic symptoms, consider changing to second line therapy; either adding metronidazole 400mg twice daily or changing to co-amoxiclav 625mg.
First line antibiotic treatment of dental abscess consists of either amoxicillin or metronidazole.
Does this patient need admission?
Very few patients presenting with dental infection require referral and admission to hospital but it is important to recognise those that do. The presence of any of the following should prompt urgent referral to a maxillofacial specialist for consideration of admission:
- Evidence of significant systemic disturbance
- Failure to control infection with antibiotics
- Rapid spread of infection
- Immunocompromised patients
- A general anaesthetic will be needed to drain an abscess
Uncommon but important diagnoses
Two uncommon but important diagnoses not to be missed in patients attending the ED are Ludwigs and Vincents angina.
Ludwigs Angina is a potentially life threatening complication of untreated dental infection. It is a rapidly progressing submaxillary, submandibular, and sublingual necrotizing cellulitis and can lead to airway obstruction and death. It requires an early diagnosis and treatment which may include an urgent surgical airway if the airway is compromised 13.
99% of cases of Ludwigs angina are odontogenic, anterior teeth often being the starting site for sublingual infection and 2nd and 3rd molars are a starting point for submaxillary space infection 14. The presentation is variable, but symptoms such as dysphagia, neck pain and tooth pain, and signs such as tongue elevation and/or protrusion and neck swelling are all common 15. There may also be signs of airway obstruction such as stridor and dyspnoea.
Protrusion of the tongue in Ludwigs angina (Reproduced with permission from Wellcome Images)
Neck swelling in Ludwigs angina (Reproduced with permission from Wellcome Images)
Swift recognition and aggressive and early intervention is paramount. Airway safety is the primary concern, followed by administration of intravenous antibiotics and consideration of surgical drainage. It is vital that, in addition to a maxillofacial specialist, an experienced anaesthetist and otolaryngologist are involved. Antibiotic therapy should follow the guidance already outlined for dental abscess.
Ludwigs angina can rapidly progress to airway compromise. Early recognition is the key to treatment.
Vincents angina (Acute Necrotising Ulcerative Gingivitis)
Vincents angina, also known as trench mouth or acute necrotising ulcerative gingivitis, is defined as an acute febrile, pseudo-membranous inflammation of the gingiva secondary to bacterial infection. The aetiology is unclear but is thought to be due to superinfection with anaerobic bacteria such as bacteroides, fusobacterium and spirochetes which are normal mouth flora. It is now more commonly found in patients with immunodeficiency states such as malnutrition and HIV infection.
The infection starts as inflammation usually on one side of the mouth which spreads along the gingival margins and may affect the pharynx and lips. This leads to gum atrophy, ulceration, enlarged lymph nodes and formation of a grey pseudo membrane, which may lead to it being confused with diphtheria.
Emergency department treatment consists of chlorhexidine mouth washes, a 3 day course of metronidazole or amoxicillin and encourage improved oral hygiene. Patients should be advised that they need urgent assessment and management by a dentist.
Acute necrotising ulcerative gingivitis
Key Learning Points
- A significant proportion of an EDs out of hours workload involves dental problems, as such a grasp of basic anatomy and history/examination skills are a must for any ED doctor (level of evidence 5)
- Toothache doesnt always mean dental pathology hence a proper history and examination is required. Consider referred cardiac pain in patients with risk factors! (level of evidence 5)
- A thorough examination of the mouth and teeth is essential to identify worrying symptoms such as stridor, dyspnoea, dysphonia and sublingual swelling which may indicate airway compromise. (level of evidence 5)
- Some patients may require admission for dental infection; these include those with features of systemic sepsis, where there is evidence of local spread of infection, immunocompromised patients and those needing a general anaesthetic. (level of evidence 5)
- Dental problems are often simple when dealt with well. However, they have the potential to progress to life threatening problems such as sepsis and airway compromise. (level of evidence 5)
- Doctors prescribe antibiotics for twice as many patients as dental practitioners. ED doctors should only administer antibiotics to patients who are immunocompromised or where there are signs of systemic infection. (level of evidence 4)
- Early identification of Ludwigs angina is vital as rapid intervention may prevent life threatening air way compromise. (level of evidence 5)
- Immunocompromised patients are far more likely to develop Vincents angina than the normal population. (level of evidence 5)
Pitfalls in the management of dental pain and infections include:
- Inability to describe the normal anatomy of the tooth and document a dental problem accurately.
- Assuming that pain in the jaw or mouth has arisen from a dental origin.
- Failure to conduct a thorough examination of the patient thereby missing signs of one of the significant complications of dental infection.
- Prescribing opiate analgesia as a first line for dental pain. NSAIDs are the most effective first line treatment for dental pain.
- Prescription of unnecessary antibiotics to a patient with dental infection.
- Failure to appreciate the potential of dental infection to cause systemic upset and compromise the airway.
- Failure to recognise Ludwigs angina and institute early airway management.
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- Patel KK, Driscoll P. Dental knowledge of accident and emergency senior house officers. Emerg Med J 2002;19:539-541
- Robertson D, Smith AJ. The microbiology of the acute dental abscess. J Med Microbiol 2009;58:155-162
- CKS (2009) Dental Abscess (Topic review) http://www.cks.nhs.uk/dental_abscess#-312242 (accessed 24th July 2009)
- BNF (2009) Analgesics review http://www.bnf.org/bnf/bnf/57/3456.htm#_3456.5 (accessed July 24th 2009)
- Anderson R, Calder L, Thomas DW. Antibiotic prescribing for dental conditions: general medical practitioners and dentists compared. Br Dent J 2000;188:398-400
- Roy KM, Bagg J. Antibiotic prescribing by general dental practitioners in the Greater Glasgow Health Board, Scotland. Br Dent J 2000;188:6746
- Palmer NOA, Martin MV, Pealing R et al. An analysis of antibiotic prescriptions from general dental practitioners in England. J Antimicrob Chemother 2000;46:10335.
- Samaranayake LP, Johnson NW. Guidelines for the use of antimicrobial agents to minimise development of resistance. Int Dent J 1999;49:18995
- BNF (2009) Antibacterial drugs http://www.bnf.org/bnf/bnf/57/3705.htm#_3705.2 (accessed July 24th 2009)
- CKS (2009) Dental Abscess (Topic review) http://www.cks.nhs.uk/dental_abscess/management/detailed_answers/waiting_to_see_a_dental_practitioner/prescribing_an_antibiotic (accessed July 24th 2009)
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